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Reumatología

Publicaciones

    2015

  • Ribeiro M, López de Figueroa P, Blanco FJ, Mendes AF, Caramés B. Insulin decreases autophagy and leads to cartilage degradation. Osteoarthritis and Cartilage. 2015: S1063-4584:01370-9.
  • Caramés B, Olmer M, Kiosses WB, Lotz MK. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model. Arthritis Rheumatol. 2015;67:1568-76.
  • López de Figueroa P, Lotz MK, Blanco FJ, Caramés B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67:966-76.
  • Cavavo S, Viegas CSB, Rafael MS, Ramos A, Magalhães J, Blanco FJ, Vermeer C, Simes, D. Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis. Cellular and Molecular Life Sciences, 09/2015.
  • Magalhães J, Lebourg M, Deplaine H, Gómez-Ribelles JL, Blanco FJ. Effect of the physicochemical properties of pure or chitosan coated-poly(L-lactic acid) scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients. Tissue Engineering Part A 2015, 21 (3-4): 716-728.
  • Burguera EF, Blanco FJ, Magalhães J. Cell Therapy and Tissue Engineering Strategies in Rheumatic Diseases. Biomateriales: Diseño, Producción y Caracterización, 2015. Ed. Red Gallega de Biomateriales. ISBN 978-84-15086-50-5.
  • Soto Hermida A, Fernández Moreno M, Pértega Díaz S, Oreiro Villar N, Fernández López C, Blanco FJ, Rego Pérez I. Mitochondrial DNA haplogroups modulate the radiographic progression of Spanish patients with osteoarthritis. Rheumatology International. 2015;35(2):337-344.
  • Rocha B, Calamia V, Blanco FJ, Ruiz-Romero C. Identification of Factors Produced and Secreted by Mesenchymal Stromal Cells with the SILAC Method. In: Mesenchymal Stem Cells: Methods and Protocols, 2015. Methods in Molecular Biology, Vol. 1416, Cap 33. ISBN: 978-1-4939-3582-6.
  • Ruiz-Romero C, Blanco FJ. What steps are needed to achieve perfect diagnostic and monitoring tests for osteoarthritis? International Journal of Clinical Rheumatology 2015; 10(3), 123–125.
  • Ruiz-Romero C, Fernández-Puente P, Calamia V, Blanco FJ. Lessons from the proteomic study of osteoarthritis. Expert Rev Proteomics 2015; 12(4):433-43.
  • Lourido L, Calamia V, Fernández-Puente P, Mateos M, Oreiro N, Blanco FJ, Ruiz-Romero C. Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint. Proteomics Clinical Applications 2015, DOI: 10.1002/prca.201400186.
  • Ruiz-Romero C, Calamia V, Albar JP, Casal JI, Corrales FJ, Fernández-Puente P, Gil C, Mateos J, Vivanco F, Blanco FJ. The Spanish Biology/Disease Initiative within the Human Proteome Project: Application to Rheumatic Diseases. Journal of Proteomics 2015, 127(Pt B):406-13.
  • Rocha B, Cillero-Pastor B, Ruiz-Romero C, Gert Eijkel, Anne Bruinen, Heeren RM, Blanco FJ. Characterization of lipidic markers of chondrogenic differentiation using MALDI Mass Spectrometry Imaging. Proteomics 2015; 15(4):702-13.
  • 2014

  • Akasaki Y, Alvarez-Garcia O, Saito M, Caramés B, Iwamoto Y, Lotz MK. FoxO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol. 2014;66:3349-58.
  • Soto Hermida A, Fernández Moreno M, Oreiro Villar N, Fernández López C, Rego Pérez I, Blanco FJ. mtDNA haplogroups and osteoarthritis in different geographic populations. Mitochondrion. Elsevier, 2014.
  • Fernández Tajes J, Soto Hermida A, Vázquez Mosquera ME, Cortés Pereira E, Mosquera Rey A, Fernández Moreno M, Oreiro Villar N, Fernández López C, Fernández García JL, Rego Pérez I, Blanco FJ. Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis. 2014 Apr;73(4):668-77.
  • Blanco FJ, Rego Pérez I. Editorial. Is it time for epigenetics in Osteoarthritis? Arthritis Rheumatol. 2014;66(9):2324-7.
  • Soto Hermida A, Fernández Moreno M, Oreiro Villar N, Fernández López C, Pértega Díaz S, Cortés Pereira E, Rego Pérez I, Blanco FJ. Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis. Data from the Osteoarthritis Initiative (OAI). PlosOne. 2014;9(11):e112735.
  • Magalhães J, Crawford A, Hatton PV, Blanco FJ, San Román J. Poly[2-ethyl-(2-pyrrolidone)methacrylate] and Hyaluronic Acid-Based Hydrogels for the Engineering of a Cartilage-like Tissue using Bovine Articular Chondrocytes. J Bioact Compat Polym 2014, 29 (6): 545-559.
  • Volkmer T, Magalhães J, Sousa V, Santos LA, Burguera EF, Blanco FJ, San Roman J, Rodriguez-Lorenzo L. 2-(Dimethylamino)ethyl methacrylate/(2-hydroxyethyl) methacrylate/α-tricalcium phosphate cryogels for tissue engineering, preparation and evaluation of the biological response of human trabecular bone-derived cells and mesenchymal stem cells. Polymers, 2014, 6 (10): 2510-2525.
  • Burguera EF, Vela Anero A, Magalhães J, Meijide-Faílde R, Blanco FJ. Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes. Osteoarthritis and Cartilage, 2014, 22 (7): 1026-35.
  • Lourido L, Calamia V, Mateos M, Fernández-Puente P, Fernández-Tajes J, Blanco FJ, Ruiz-Romero C. Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis. Journal of Proteome Research 2014; 13 (12): 6096-6106.
  • F Henjes, L Lourido, C Ruiz-Romero, J Fernandez-Tajes, JM Schwenk, M Gonzalez-Gonzalez, FJ Blanco, P Nilsson, M Fuentes. Analysis of autoantibody profiles in osteoarthritis using comprehensive protein array concepts. Journal of Proteome Research 2014; 13 (11): 5218-5229.
  • Calamia V, Mateos J, Fernández-Puente P, Lourido L, Rocha B, Fernández-Costa C, Montell E, Vergés J, Ruiz-Romero C, Blanco FJ. A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine. Scientific Reports 2014; 4:5069.
  • Fernández-Costa C, Revoiro-Jato M, Fdez.-Riverola F, Ruiz-Romero C, Blanco FJ, Capelo-Martínez JL. Sequential depletion coupled to C18 sequential extraction as a rapid tool for human serum multiple profiling. Talanta 2014; 125:189-195.
  • Mateos J, Pintor-Iglesias A, Fernandez-Puente P, García-Camba M, Ruiz-Romero C, Domenech N, Blanco FJ. Cryoconservation of peptide extracts from trypsin digestion of proteins for proteomics analysis in a hospital biobank facility. Journal of Proteome Research 2014; 13 (4): 1930-37.
  • Rocha B, Calamia V, Casas V, Carrascal M, Blanco FJ, Ruiz-Romero C. Secretome analysis of human mesenchymal stem cells undergoing chondrogenic differentiation. Journal of Proteome Research 2014; 13(2):1045-54.
  • Segura V, Medina-Aunon A, Mora MI, Martínez-Bartolomé S, Abian J, Aloria K, Antúnez O, Arizmendi JM, Azkargorta M, Barceló-Batllori S, Beaskoetxea J, Bech-Serra JJ, Blanco FJ, Monteiro MB, Cáceres D, Canals F, Carrascal M, Casal JI, Clemente F, Colome N, Dasilva N, Díaz P, Elortza F, Fernández-Puente P, Fuentes M, Gallardo O, Gharbi SI, Gil C, González-Tejedo C, Hernáez ML, Lombardia M, Lopez-Lucendo MI, Marcilla M, Mato JM, Mendes ML, Oliveira E, Orera I, Pascual-Montano A, Prieto G, Ruiz-Romero C, Sánchez Del Pino MM, Tabas-Madrid D, Valero ML, Vialas V, Villanueva J, Albar JP, Corrales FJ. Surfing transcriptomic landscapes. A step beyond the annotation of Chromosome 16 proteome. Journal of Proteome Research 2014; 13(1):158-172.
  • 2013

  • Caramés B, Kiosses WB, Akasaki Y, Brinson DC, Eap W, Koziol J, Lotz MK. Glucosamine activates autophagy in vitro and in vivo. Arthritis Rheum, 2013;65:1843-52.
  • Rego Pérez I, Fernández Moreno M, Soto Hermida A, Fernández López C, Oreiro Villar N, Blanco FJ. Mitochondrial genetics and osteoarthritis. Front Biosci (Schol Ed.), 2013. 5, pp. 360 - 368.
  • Fernandez-Caggiano M, Barallobre-Barreiro J, Rego-Perez I, Crespo-Leiro MG, Paniagua MJ, Grille Z, Blanco FJ, Domenech N. Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population. Mitochondrion, 2013. 13 - 4, pp. 263 - 268. ISSN 1567-7249.
  • Mayan MD, Gago-Fuentes R, Carpintero-Fernandez P, Fernandez-Puente P, Filgueira-Fernandez P, Goyanes N, Valiunas V, Brink PR, Goldberg GS, Blanco FJ. Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis. Ann Rheum Dis. 2013.
  • Cicione C, Muiños-López E, Hermida-Gómez T, Fuentes-Boquete I, Díaz-Prado S, Blanco FJ. Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential. Stem Cells Int. 2013;2013:232896.
  • Mateos J, De la Fuente A, Lesende-Rodriguez I, Fernández-Pernas P, Arufe MC, Blanco FJ. Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress. Stem Cell Res. 2013;11(3):1137-48.
  • Cillero-Pastor B, Rego-Pérez I, Oreiro N, Fernandez-Lopez C, Blanco FJ. Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture. BMC Musculoskelet Disord. 2013;14:235.
  • Magalhães J, Crawford A, Hatton PV, Blanco FJ, San Román J. Mineralization of porous hydrogels based on sIPN of PEPMHA in SBF. J Bioact Compat Polym, 2013, 28 (5): 468-480.
  • Magalhães J, Sousa RA, Mano JF, Reis RL, Blanco FJ, San Román J. Synthesis and characterization of sensitive hydrogels based on semi-interpenetrated networks of poly[2-ethyl-(2-pyrrolidone) methacrylate] and hyaluronic acid. J Biomed Mater Res A. 2013;101(1):157-66.
  • Ruiz-Romero C, Blanco FJ. Achievements and challenges of proteomics in the study of rheumatoid arthritis. Curr Top Med Chem. 2013;13(6):732-42.
  • Blanco FJ, Ruiz-Romero C. New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1. Ann Rheum Dis. 2013;72(5):631-4.
  • Fernandez-Costa C, Ruiz-Romero C, Blanco FJ, Santos HM, Capelo JL. An assessment of the indirect high intensity ultrasonic assisted cleavage of complex proteomes with immobilized trypsin. Talanta 2013; 106: 163-168.
  • Mayan MD, Carpintero-Fernandez P, Gago-Fuentes R, Martinez-de-Ilarduya O, Wang HZ, Valiunas V, Brink P, Blanco FJ. Human articular chondrocytes express multiple gap junction proteins: differential expression of connexins in normal and osteoarthritic cartilage. Am J Pathol. 2013;182(4):1337-46.
  • 2012

  • Lotz M, Caramés B. Autophagy: a new therapeutic target in cartilage injury and osteoarthritis. J Am Acad Orthop Surg. 2012;20:261-2.
  • Caramés B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis. 2012;71:575-81.
  • Caramés B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. Arthritis Rheum. 2012;64:1182-92.
  • Fernández-Moreno M, Soto-Hermida A, Oreiro N, Pértega S, Fernández-López C, Rego-Pérez I, Blanco FJ. Mitochondrial haplogroups define two phenotypes of Osteoarthritis. Front Phys. 2012,3:129.Fernandez-Caggiano M, Barallobre-Barreiro J, Rego-Perez I, Crespo-Leiro MG, Paniagua MJ, Grille Z, Blanco FJ, Domenech N. Mitochondrial Haplogroups H and J: Risk and Protective Factors for Ischemic Cardiomyopathy. PLoS One. 7 - 8, 2012. ISSN 1932-6203.
  • Rocha B, Calamia V, Mateos J, Fernández-Puente P, Blanco FJ, Ruiz-Romero, C. Metabolic labeling of human bone marrow mesenchymal stem cells for the quantitative analysis of their chondrogenic differentiation. J Proteome Res. 2012;11(11):5350-61.
  • Fernandez-Costa C, Calamia V, Fernandez-Puente P, Capelo JL, Ruiz-Romero C, Blanco FJ. Sequential depletion of human serum for the search of osteoarthritis biomarkers. Proteome Science 2012; 10(1): 55.
  • Calamia V, Lourido L, Fernandez-Puente P, Mateos M, Rocha B, Montell E, Verges J, Ruiz-Romero C, Blanco FJ. Secretome analysis of chondroitin sulfate – treated chondrocytes reveals its anti-angiogenic, anti-inflammatory and anti-catabolic properties. Arthritis Research and Therapy 2012; 14:R202.
  • Blanco FJ, Ruiz-Romero C. Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA. Nature Reviews in Rheumatology 2012; 8:130-132.
  • Calamia V, Fernandez-Puente P, Mateos M, Rocha B, Lourido L, Montell E, Verges J, Ruiz-Romero C, Blanco FJ. Pharmacoproteomic study of the effect of three different chondroitin sulfate compounds on chondrocyte intracellular and extracellular proteomes. Molecular and Cellular Proteomics 2012, 11(6): M111.013417.
  • Mateos M, Lourido L, Fernandez-Puente P, Calamia V, Fernandez-Lopez C, Oreiro N, Ruiz-Romero C, Blanco FJ. Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LCMALDI TOF/TOF. Journal of Proteomics 2012, 75: 2869-2878.
  • 2011

  • Taniguchi N, Caramés B, Hsu E, Cherqui S, Kawakami Y, Lotz M. Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation. J Biol Chem. 2011;286:41489-98.
  • Lotz MK, Caramés B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol. 2011;7:579-87.
  • Fernandez-Moreno M, Hermida A, Pertega S, Oreiro N, Fernandez-Lopez C, Rego-Pérez I Blanco FJ. mtDNA Haplogroups and serum levels of anti-oxidants enzymes in patients with Osteoarthritis. BMC Musculoskeletal Dis. 2011,22;12:264.
  • Rego-Pérez I, Fernández-Moreno M, Deberg M, Pértega S, Fernández-López C, Oreiro N, Henrotin Y, Blanco FJ. mtDNA haplogroups and serum levels of proteolytic enzymes in patients with osteoarthritis. Ann Rheum Dis 2011, 70:646–652.
  • K Panoutsopoulou, L Southam, KS Elliott, N Wrayner, G Zhai, C Beazley, G Thorleifsson, NK Arden, A Carr, K Chapman, P Deloukas, M Doherty, A McCaskie, WER Ollier, SH Ralston, TD Spector, AM Valdes, GA Wallis, JM Wilkinson, E Arden, K Battley, H Blackburn, FJ Blanco, S Bumpstead, LA Cupples, AG DayWilliams, K Dixon, SA Doherty, T Esko, E Evangelou, D Felson, JJ Gomez Reino, A Gonzalez, A Gordon, R Gwilliam, BV Halldorsson, VB Hauksson, A Hofman, S E Hunt, JPA Ioannidis, T Ingvarsson, I Jonsdottir, H Jonsson, R Keen, HJM Kerkhof, MG Kloppenburg, N Koller, N Lakenberg, NE Lane, AT Lee, A Metspalu, I Meulenbelt, MC Nevitt, F O’Neill, N Parimi, SC Potter, I Rego-Pérez, JA Riancho, K Sherburn, PE Slagboom, K Stefansson, U Styrkarsdottir, M Sumillera, D Swift, U Thorsteinsdottir, A Tsezou, AG Uitterlinden, JBJ van Meurs, B Watkins, M Wheeler, S Mitchell, Y Zhu, JM Zmuda; arcOGEN Consortium, E Zeggini, J Loughlin. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis 2011,70:864–867.
  • Tamayo M, Mosquera A, Rego-Pérez I, Blanco FJ, Gosálvez J, Fernández JL. Decreased length of telomeric DNA sequences and increased numerical chromosome aberrations in human osteoarthritic chondrocytes. Mutat Res: Fundam Mol Mech Mutagen 2011, 708:50-58.
  • Blanco FJ, Rego-Pérez I, and Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol 2011, 7:161-169.
  • Fernández-Moreno M, Tamayo M, Soto-Hermida A, Mosquera A, Oreiro N, Fernández-López C, Fernández JL, Rego-Pérez I, Blanco FJ. mtDNA haplogroup J modulates telomere length and Nitric Oxide production. BMC Musculoskeletal Dis 2011,15;12:283.
  • Cillero-Pastor B, Mateos J, Fernández-López C, Oreiro N, Ruiz-Romero C, Blanco FJ. Dimethylarginine Dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes. Arthritis and Rheumatism 2011; 64 (1): 204-212.
  • Calamia V, de Andres MC, Oreiro N, Ruiz-Romero C, Blanco FJ. Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes. BMC Musculoskeletal Disorders 2011; 12: 237.
  • Fernandez-Puente P, Mateos M, Fernandez-Costa C, Ruiz-Romero C, Blanco FJ. Identification of a panel of novel serum osteoarthritis biomarkers. Journal of Proteome Research 2011; 10 (11): 5095-5101.
  • Fernandez C, Santos HM, Ruiz-Romero C, Blanco FJ, Capelo JL. A comparison of depletion vs. equalization for reducing high abundance proteins in human serum. Electrophoresis 2011; 32 (21): 2966-2974.
  • Calamia V, Rocha B, Mateos J, Fernandez-Puente P, Ruiz-Romero C, Blanco FJ. Metabolic labeling of chondrocytes for the quantitative analysis of the interleukin-1-beta-mediated modulation of their intracellular andextracellular proteomes. Journal of Proteome Research 2011; 10 (8): 3701-3711.
  • 2010

  • Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010;62:791-801.
  • Cillero-Pastor B, Ruiz-Romero C, Caramés B, López-Armada MJ, Blanco FJ. Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor alpha and interleukin-1beta. Arthritis Rheum. 2010;62:802-14. PubMed PMID: 20131227.
  • Calamia V, Ruiz-Romero C, Rocha B, Fernandez-Puente P, Mateos J, Montell E, Verges J, Blanco FJ. Proteomic evaluation of the chondroprotective effect of chondroitin and glucosamine sulphate on human articular chondrocytes. Arthritis Research and Therapy 2010; 12 (4), R138.
  • Ruiz-Romero C, Calamia V, Rocha B, Mateos J, Fernandez-Puente P, Blanco FJ. Hypoxia conditions differentially modulate normal and osteoarthritic chondrocyte proteomes. Journal of Proteome Research 2010; 9 (6): 3035-3045.
  • Ruiz-Romero C, Blanco FJ. Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis. Osteoarthritis and Cartilage 2010; 18 (4): 500- 509.
  • Ruiz-Romero C, Calamia V, Carreira V, Mateos J, Fernandez P, Blanco FJ. Strategies to optimize twodimensional gel electrophoresis analysis of the human joint proteome. Talanta 2010; 80(4): 1552-1560.
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